Related Experiment Video
Updated: Aug 12, 2026
Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury
Published on: December 17, 2014
[Perinatal brain damage--from neuroprotection to neuroregeneration using cord blood stem cells]
Arne Jensen1, Hans-Martin Vaihinger, Carola Meier
1Zentrum für Perinatalmedizin, Experimentelle Perinatologie, Universitätsfrauenklinik Bochum, Ruhr-Universität Bochum. arne.jensen@ruhr-uni-bochum.de
Insights
Perinatal hypoxic-ischemic insults cause brain damage in about 1,000 German children annually. Research explores cord blood stem cells for neuroregeneration to mitigate this damage.
Area of Science:
- Perinatology
- Neuroscience
- Regenerative Medicine
Background:
- Approximately 1,000 children in Germany annually experience brain damage from perinatal hypoxic-ischemic insults.
- These insults can lead to various neurological impairments, including spastic paresis, choreoathetosis, ataxia, and sensorimotor dysfunction.
- The significant physical, emotional, and financial burden necessitates advanced therapeutic strategies.
Purpose of the Study:
- To highlight the need for effective neuroprotective and regenerative therapies post-insult.
- To explore the potential of novel treatments for reducing cerebral morbidity in newborns.
- To investigate the application of cord blood-derived stem cells for neuroregeneration.
Main Methods:
- Review of clinical concepts for decreasing cerebral morbidity.
- Analysis of experimental pilot studies on neuroprotection.
- Focus on current research into cord blood stem cell applications for brain injury.
Main Results:
- Clinical concepts have shown effectiveness in reducing morbidity over the past decade.
- Experimental pilot studies show promise for neuroprotective interventions.
- Current research is actively investigating cord blood stem cells for neuroregeneration.
Conclusions:
- While clinical measures have improved, brain damage cannot always be prevented.
- Developing post-insult therapeutic measures with neuroprotective effects is crucial.
- Cord blood-derived stem cells represent a promising avenue for neuroregeneration in affected children.
Abstract:
Per year, approximately 1,000 children in Germany suffer from brain damage due to hypoxic-ischemic insults during the perinatal period. Based on the severity and localization of the insult, these children develop either spastic pareses, choreoathetosis, ataxia, or sensomotoric dysfunctions. A close cooperation between obstetricians, pediatricians, neuropediatricians, physical therapists, developmental psychologists, and other specialists is required, as the strain these disorders have on the children and their families is tremendous. The costs resulting per birthyear for the community are estimated on 1 million Euro. Clinical concepts to decrease the cerebral morbidity in perinatology departments have proven to be effective over the last decade. However, since brain damage cannot be prevented every time, it is essential that therapeutic measures, which have a neuroprotective effect after the insult, are being developed. Experimental pilots regarding these matters are promising. Current experiments are focused on the possible application of cord blood-derived stem cells for neuroregeneration.
More Related Videos
Related Concept Videos
00:49The Blood-brain Barrier
01:15Neurogenesis and Regeneration of Nervous Tissue