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The burden of complex genetics in brain disorders
1Molecular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. guhl@intra.nida.nih.gov
Archives of General Psychiatry
|March 3, 2004
Summary
Complex genetics significantly impacts neuropsychiatric disorders, contributing over 40% to the societal burden. Understanding these genetic factors is crucial for advancing prevention and treatment strategies.
Area of Science:
- Neuroscience
- Genetics
- Public Health
Background:
- The impact of complex genetics on neuropsychiatric illnesses is often underestimated.
- Limited data exist on the full societal cost of these conditions.
Purpose of the Study:
- To estimate the economic and societal impact of complex genetics in US neuropsychiatric disorders.
- To quantify the heritability and Mendelian contributions to these conditions.
Main Methods:
- Economic costs were derived from literature and updated estimates.
- Heritability was assessed using twin study data.
- Mendelian contributions were analyzed using the Online Mendelian Inheritance in Man database.
Main Results:
- Brain and nervous system disorders incur annual costs up to $1.2 trillion in the US.
- Over 40% of the societal burden of brain disorders is likely genetically mediated.
- Complex, multigene genetics and environmental factors drive most of this disease burden.
Conclusions:
- The substantial genetic contribution to brain disorders necessitates further research.
- Linking genetic variants to pathogenesis, diagnostics, and therapeutics is essential.
- This research highlights the need for molecular and clinical advancements in understanding brain disorder genetics.