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Updated: Aug 9, 2026

DNA Transfection of Mammalian Skeletal Muscles using In Vivo Electroporation
Published on: October 19, 2009
Systemic administration of naked DNA: gene transfer to skeletal muscle
1Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, PA 15213, USA.
Abstract:
Skeletal muscle is a promising target tissue for the gene therapy of both muscle and non-muscle disorders. Gene transfer into muscle tissue can produce a variety of physiologically active proteins and may ultimately be applied to the treatment of many diseases. A variety of methods have been studied to transfer genes into skeletal muscle, including viral and non-viral vectors. In this review, we discuss recent developments in the non-viral delivery of genes to muscles.
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