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Chronic hepatotoxicity of carbon tetrachloride in hsp-70 knock out mice
Dae-Hun Park1, Mi-Sook Lee, Heui-Jin Kim
1Laboratory of Immunopharmacology, Department of Veterinary Medicine, Kangwon National University, Korea.
Abstract:
The chronic hepatotoxic effects of carbon tetrachloride (CCl(4)) in heat-shock protein (HSP) 70 knock out (HSP70-/-) mice were examined. After repeated intraperitoneal injections of CCl(4) for six weeks, the level of ALT and weight ratio of the liver to body were lower in HSP70-/- mice than in the control (WT) mice. The levels of HSP25 and HSP47 were lowered in HSP70-/- mice as compared with WT mice. The grades of hepatic necrosis and neutrophil infiltration were not significantly different between HSP70-/- and WT mice. The collagen content was not affected significantly by CCl(4) treatment.
