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Published on: August 16, 2018
Oleanane triterpenoids with inhibitory activity against NFAT transcription factor from Liquidambar formosana
Nguyen Tien Dat1, Im Seon Lee, Xing Fu Cai
1College of Pharmacy, Chungnam National University, Daejeon, Korea.
Abstract:
In a search for inhibitory components from natural products against NFAT transcription factor, this study investigated the ethyl acetate extract of the fruits of Liquidambar formosana. Four oleanane triterpenoids were isolated and identified to be liquidambaric acid, oleanolic acid, 3alpha-acetoxy-25-hydroxy-olean-12-en-28-oic acid and lantanolic acid. Of these compounds, 3alpha-acetoxy-25-hydroxy-olean-12-en-28-oic acid (IC50: 4.63 microM) and lantanolic acid (IC50: 12.62 microM) exhibited strong inhibitory activity against the NFAT transcription factor.
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