Related Experiment Video
Updated: Aug 26, 2026

Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models
Published on: April 26, 2024
[A comparison of lanthanum contained rinse on acid resistant abilities to human enamel and root surface]
1Department of Pathology, Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
Objective:
To compare the effect of different does of lanthanum-contained rinse solution on carious-resistance, and to investigate the acid-resistant abilities of dental enamel and root surface that treated with lanthanum-contained rinse solution.
Methods:
Human dental root surfaces were treated in vitro with various doses (100 x 10(-6) - 2000 x 10(-6)) of lanthanum-contained rinse solution under the pH cycle environment that mimic the normal pH change curve of oral cavity. The qualitative and quantitative analysis was carried out on dental cementum according to their mineralized degrees. The best effective dose for carious-resistance was set for further investigation in vitro. Dental enamel and root surfaces were treated with the rinse for 1 hour each day, total for five days.
Results:
The rinse solution containing 500 x 10(-6) lanthanum or more than it showed a obvious carious-resistant effect and there was no significant difference between root surfaces and dental enamel while treated with 500 x 10(-6) lanthanum-contained rinse solution. To compare demineralized degrees between enamel and root surfaces before or after treatment, enamel showed severer demineralization than root surfaces.
Conclusion:
500 x 10(-6) lanthanum-contained rinse solution is considered to be the lowest effective dose for carious-resistance, and lanthanum-contained rinse solution is especially suitable for the treatment and prevention of dental root caries.
