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Updated: Aug 26, 2026

Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair
Published on: May 23, 2014
[The effects of apoptosis during fracture healing]
1Research Institute of Stomatology, Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
Objective:
To elucidate the occurrence and significance of apoptosis during fracture healing of the mandible.
Methods:
An experimental model of fracture was established to detect apoptosis in the different stages of healing by TdT-mediated dUTP nick end-labeling (TUNEL) method.
Results:
Apoptosis was observed in the whole healing process. The apoptotic cells markedly increased in the stage of intramembranous bone formation (5d) and chondrogenesis (11d).
Conclusion:
Apoptosis is involved in fracture healing. The number of cells was controlled and the useless cells were eliminated by means of apoptosis. This process is helpful to the healing of tissues.
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