Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Mucosal changes in rhinitis medicamentosa.

Chun-Yu Lin¹, Po-Hsu Cheng, Sheen-Yie Fang

¹Department of Otolaryngology, National Cheng Kung University Hospital, Tainan, Taiwan.

The Annals of Otology, Rhinology, and Laryngology

|March 5, 2004

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Human parvovirus B19 VP1u‑induced osteoclastogenesis is enhanced by RANKL in RAW264.7 macrophage cells.

Molecular medicine reports·2026

Same author

Upper Limb Tremors Classification for Parkinson's Disease Using W-Band (76-81 GHz) Doppler Millimeter-Wave Sensing and Deep-Learning-Based Classifier.

Sensors (Basel, Switzerland)·2026

Same author

Re-evaluating the 14-day rule: short-course antifungal therapy for uncomplicated candidaemia in a multicentre cohort study.

The Journal of antimicrobial chemotherapy·2026

Same author

Hyperoside protects against poly-GR-mediated neurodegeneration via regulation of mitochondrial fission and oxidative stress in C9orf72-associated ALS.

Chinese medicine·2026

Same author

Outcomes of concomitant <i>Pneumocystis jirovecii</i> pneumonia and cytomegalovirus co-infection in non-HIV, mechanically ventilated critically ill patients.

Annals of medicine·2026

Same author

Differentiating leptospirosis from Rickettsial diseases and Q fever: A syndrome-based study in Southern Taiwan.

Tropical doctor·2026

Same journal

Laryngeal Injuries Following General Endotracheal Anesthesia: A Case Series.

The Annals of otology, rhinology, and laryngology·2026

Same journal

Clinical and Voice Outcome Differences in Vocal Cord Cysts with and Without Sulcus Vocalis: Insights From a Tertiary Center in Saudi Arabia.

The Annals of otology, rhinology, and laryngology·2026

Same journal

Bioabsorbable Stenting in a Case of Severe Pediatric Posterior Glottic Stenosis.

The Annals of otology, rhinology, and laryngology·2026

Same journal

Efficacy and Safety of Finafloxacin Otic Suspension, 0.3% for the Treatment of Acute Otitis Externa: Results from two Phase III Randomized Clinical Studies.

The Annals of otology, rhinology, and laryngology·2026

Same journal

Evaluation Of the Expression Levels Of SerpinB3/B4/B10, Interleukin-17 As Biomarkers For Chronic Rhinosinusitis With Nasal Polyps.

The Annals of otology, rhinology, and laryngology·2026

Same journal

Correlation of Patient-Reported Symptoms With Rhinogram Features Beyond Simple Airway Resistance.

The Annals of otology, rhinology, and laryngology·2026

See all related articles

Rhinitis medicamentosa (RM) causes significant nasal mucosal changes, including goblet cell hyperplasia and altered subepithelial glands. These changes contribute to a chronic inflammatory, hypersecretory state, impacting nasal function.

Area of Science:

Otorhinolaryngology
Pathology
Cell Biology

Background:

Rhinitis medicamentosa (RM) is a condition characterized by chronic nasal inflammation.
Understanding the specific mucosal changes in RM is crucial for effective treatment.

Purpose of the Study:

To investigate the ultrastructural and cellular changes in the nasal mucosa of patients with RM.
To compare these changes with chronic hypertrophic rhinitis (CHR) and normal nasal mucosa.

Main Methods:

Analysis of inferior turbinate mucosal specimens from patients with RM, CHR, and healthy controls.
Utilized scanning electron microscopy and immunohistochemical staining for epidermal growth factor receptor (EGFR).

Main Results:

Related Experiment Videos

Prominent goblet cell hyperplasia observed in the RM group.

Increased subepithelial gland openings noted in both RM and CHR groups.

Strongest EGFR immunoreactivity found in the hyperplastic epithelium of RM patients.

Conclusions:

Nasal mucosa in RM exhibits a chronic inflammatory and hypersecretory state.
Degenerative changes in secretory elements may impair mucociliary transport.
These alterations likely contribute to nasal obstruction and posterior nasal drip in RM.