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Pressure-induced ordering in mixed-lipid bilayers.

Andre Brown¹, Ian Skanes, Michael R Morrow

¹Department of Physics and Physical Oceanography, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1B 3X7.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics

|March 5, 2004

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Hydrostatic pressure enhances order in phospholipid bilayers, affecting lipid chain orientation. The study reveals how lipid properties and bilayer composition influence this pressure response, crucial for membrane structure.

Area of Science:

Biophysics
Materials Science
Physical Chemistry

Background:

Phospholipid bilayers form cell membranes and are model systems for studying membrane properties.
Hydrostatic pressure is a physical parameter that can alter membrane structure and function.
Understanding how pressure affects lipid order is key to comprehending membrane mechanics.

Purpose of the Study:

To investigate the effect of hydrostatic pressure on lipid chain orientational order in single-component and binary mixtures of phospholipid bilayers.
To compare the influence of intrinsic lipid properties versus collective bilayer properties on pressure-induced changes in order.
To elucidate how pressure response is distributed among components with differing lipid characteristics.

Main Methods:

Related Experiment Videos

Utilized deuterium nuclear magnetic resonance (2H NMR) spectroscopy.

Applied isothermal hydrostatic pressure to phospholipid bilayers.

Studied single-component and binary mixtures of lipids with varying chain lengths and saturation.

Main Results:

Hydrostatic pressure increases chain segment orientational order and chain extension in liquid crystalline phospholipid bilayers.
The response of chain order to pressure in single-component bilayers is dependent on the temperature relative to the lipid's phase transition temperature.
In binary mixtures, the differences in orientational order between lipid components are largely conserved under pressure.

Conclusions:

The study provides insights into the distribution of pressure response across interacting lipid components with distinct properties.
Demonstrates the sensitivity of the bilayer's interior chain ordering potential to its overall composition.
Highlights the role of both individual lipid characteristics and collective bilayer behavior in mediating pressure effects on membrane order.