Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Facial variations in sensory responses.

Marie Marriott1, Ed Whittle, David A Basketter

  • 1Safety and Environmental Assurance Centre, Unilever Colworth Laboratory, Sharnbrook, Bedford, MK44 1LQ, UK.

Contact Dermatitis
|March 5, 2004
PubMed
Summary

Facial skin sensitivity varies by region. Applying lactic acid revealed that occluded sites had lower stinging responses than unoccluded ones, indicating occlusion reduces skin sensitivity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative risk assessment of skin sensitising pesticides: Clinical and toxicological considerations.

Regulatory toxicology and pharmacology : RTP·2023
Same author

Specificity of the local lymph node assay (LLNA) for skin sensitisation.

Regulatory toxicology and pharmacology : RTP·2023
Same author

Risk management of skin sensitisers: A commentary.

Regulatory toxicology and pharmacology : RTP·2023
Same author

Comment on "Reduced specificity for the local lymph node assay for lipophilic chemicals: Implications for the validation of new approach methods for skin sensitization" ().

Regulatory toxicology and pharmacology : RTP·2023
Same author

Plant extracts, polymers and new approach methods: Practical experience with skin sensitization assessment.

Regulatory toxicology and pharmacology : RTP·2023
Same author

Enzymes and sensitization via skin exposure: A critical analysis.

Regulatory toxicology and pharmacology : RTP·2022

Area of Science:

  • Dermatology
  • Sensory Science
  • Cosmetic Science

Background:

  • Subjective skin sensations like stinging, itching, and burning often occur without visible irritation.
  • This discomfort can discourage the use of otherwise effective skincare products.

Purpose of the Study:

  • To assess facial anatomical region sensitivity to lactic acid.
  • To identify the facial area with the most intense stinging response.
  • To investigate the impact of occlusion on sensory responses.

Main Methods:

  • 45 volunteers received 10% lactic acid application on the nasolabial fold, forehead, chin, and cheek.
  • Sites were tested both occluded and unoccluded for 8 minutes.
  • Sensory reactions (stinging) were recorded at 2.5, 5, and 8 minutes.

Main Results:

  • Occluded sites showed significantly lower stinging responses compared to unoccluded sites.
  • A trend suggested females might be more sensitive than males, though not conclusively.
  • Reactions on the nasolabial fold did not always correlate with reactions on other sites like the forehead.

Conclusions:

  • Facial skin sensitivity to stinging varies across different anatomical regions.
  • Occlusion significantly reduces the stinging response to lactic acid.
  • Nasolabial fold sensitivity does not reliably predict stinging responses in other facial areas, impacting product formulation and testing.

Related Experiment Videos