Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Parathyroid Glands

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

Hyperthyroidism I: Introduction

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...

Hyperthyroidism II: Pathophysiology

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

Graves Disease II: Pathophysiology

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Single Centre Feasibility Study of Vacuum Assisted Breast Biopsy Excision as a Non-Surgical Alternative for Selected Women With Borderline Breast Lesions.

ANZ journal of surgery·2026

Same author

Characteristics and management of women with a new breast cancer diagnosis after previous breast cancer in Australia and New Zealand.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2026

Same author

NANETS Guidelines for the diagnosis and management of stage I-III rectal neuroendocrine tumors.

Endocrine-related cancer·2026

Same author

A Phase 1 Randomized Study: Garadacimab Pharmacokinetics, Safety, and Tolerability After Administration via Autoinjector/Pre-Filled Pen Versus Pre-Filled Syringe in Healthy Participants.

Journal of clinical pharmacology·2025

Same author

Delivering oral healthcare for people with cystic fibrosis: A survey of dental practitioners in Ireland.

Public health challenges·2025

Same author

Giant lipoma in the anterior region of the neck: A case report of a rare condition and review of literature.

Radiology case reports·2025

Search research articles

Related Experiment Video

Updated: Jul 9, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Pasieka Illness Questionnaire: its value in primary hyperparathyroidism.

Benedikt Greutelaers¹, Katrin Kullen, James Kollias

¹Breast Endocrine and Surgical Oncology Unit, Department of Endocrinology, Royal Adelaide Hospital, University of Adelaide, South Australia, Australia.

ANZ Journal of Surgery

|March 5, 2004

Summary

The Pasieka Illness Questionnaire effectively measures symptoms in primary hyperparathyroidism patients. Parathyroid surgery significantly improves patient quality of life and reduces disease-specific symptoms.

More Related Videos

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Measuring Psoriasis Severity at Home

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Related Experiment Videos

Last Updated: Jul 9, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Measuring Psoriasis Severity at Home

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Area of Science:

Endocrinology
Surgical Outcomes
Patient-Reported Outcomes

Background:

Primary hyperparathyroidism (1°HPT) impacts patient well-being.
Assessing surgical impact on 1°HPT symptoms is crucial.
The Pasieka Illness Questionnaire (PIQ) was developed for this purpose.

Purpose of the Study:

To evaluate the Pasieka Illness Questionnaire (PIQ) as a clinical tool in Australia.
To assess the effectiveness of parathyroid surgery for 1°HPT.
To measure changes in patient-reported symptoms and quality of life post-surgery.

Main Methods:

Prospective study of 60 patients with 1°HPT.
PIQ administered preoperatively and at 3 months post-surgery.
Quality of life and health scales used at 12-month follow-up.

Main Results:

80% of patients reported significant symptom reduction post-surgery.
Improved quality of life and self-rated health observed.
97% of patients achieved normal serum calcium levels at 12 months.

Conclusions:

The PIQ is a valid tool for assessing 1°HPT symptoms in Australian patients.
Parathyroid surgery significantly alleviates preoperative symptoms.
The study confirms the benefits of surgery for 1°HPT.