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Clinical features of thin basement membrane disease and associated glomerulopathies

Yuh-Mou Sue1, Jeng-Jong Huang, Ryh-Yaw Hsieh

  • 1Department of Internal Medicine, Taipei Medical University Municipal Wan Fang Hospital, Taipei, Taiwan.

Nephrology (Carlton, Vic.)
|March 5, 2004
PubMed
Abstract

Insights

Thin basement membrane disease (TBMD) is often benign. Associated glomerulopathies (GNs), not TBMD itself, determine the renal disease outcome and prognosis.

Area of Science:

  • Nephrology
  • Pathology
  • Glomerular Diseases

Background:

  • Thin basement membrane disease (TBMD) is found in 5-11% of renal biopsies.
  • Its association with other glomerulopathies (GNs) and subsequent prognosis are not well-documented.

Purpose of the Study:

  • To determine the prevalence, clinical features, and prognosis of TBMD.
  • To investigate the impact of co-existing GNs on TBMD outcomes.

Main Methods:

  • Retrospective analysis of 658 native kidney biopsies from June 1990 to May 2001.
  • Comparison of clinicopathological features between TBMD-only and TBMD with GN groups.
  • Mean follow-up of 44.9 months.

Main Results:

  • TBMD prevalence was 7.9% (52/658) with a mean GBM thickness of 206 nm.
  • TBMD-only group showed benign findings: microscopic hematuria, minimal proteinuria, low hypertension, and no progression.
  • TBMD with GN group presented with heavy proteinuria, hypoalbuminemia, and renal insufficiency.

Conclusions:

  • TBMD is likely a developmental abnormality with minimal clinical significance.
  • The prognosis of renal disease in patients with TBMD is primarily determined by the co-existing glomerulopathy.

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