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Related Experiment Videos

Diltiazem-induced photodistributed hyperpigmentation.

Molly Boyer1, Rajani Katta, Ramsey Markus

  • 1Department of Dermatology, Baylor College of Medicine, Houston.

Dermatology Online Journal
|March 5, 2004
PubMed
Summary
This summary is machine-generated.

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Diltiazem, a cardiovascular drug, can cause skin hyperpigmentation, particularly on sun-exposed areas. This report details two cases of this rare side effect, highlighting the need for awareness among healthcare providers.

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Diltiazem is a widely used calcium-channel antagonist for cardiovascular conditions.
  • Cutaneous reactions to diltiazem are known, but hyperpigmentation is rarely documented.

Observation:

  • Two male patients, one 71-year-old Black and one 49-year-old Hispanic, developed hyperpigmentation.
  • The hyperpigmentation appeared on sun-exposed areas of the skin.

Findings:

  • Both patients were taking an extended-release formulation of diltiazem hydrochloride (Tiazac).
  • The observed hyperpigmentation is characteristic and linked to diltiazem use.

Implications:

  • This study adds to the limited literature on diltiazem-induced hyperpigmentation.
  • Clinicians should consider diltiazem as a potential cause of hyperpigmentation in patients presenting with these symptoms, especially on sun-exposed skin.

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