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Relation between C-reactive protein, treadmill exercise testing, and inducible myocardial ischemia
Jeryes Shehadeh1, Basil S Lewis, Giora Weisz
1Department of Cardiology, Lady Davis Carmel Medical Center and Bruce Rappaport School of Medicine, Technion-IIT, Haifa, Israel.
The American Journal of Cardiology
|March 5, 2004
Summary
High-sensitivity C-reactive protein (CRP) levels correlate with exercise capacity but not with exercise-induced myocardial ischemia in stable patients. This finding suggests CRP
Area of Science:
- Cardiology
- Clinical Biochemistry
- Exercise Physiology
Background:
- High-sensitivity C-reactive protein (CRP) is an inflammatory marker.
- Exercise testing is crucial for assessing cardiovascular health.
- The relationship between CRP, ischemia, and exercise tolerance requires further elucidation.
Purpose of the Study:
- To investigate the association between high-sensitivity CRP levels and exercise-induced myocardial ischemia.
- To examine the correlation between high-sensitivity CRP and exercise tolerance in stable patients.
Main Methods:
- Maximal treadmill stress testing was performed on 288 stable patients.
- High-sensitivity C-reactive protein (CRP) levels were measured.
- Peak exercise workload and evidence of ischemia were assessed.
Main Results:
- CRP showed a correlation with peak exercise workload.
- No significant correlation was found between high-sensitivity CRP and stress-induced myocardial ischemia.
- This lack of correlation aligns with previous findings regarding CRP and coronary artery narrowing.
Conclusions:
- High-sensitivity CRP is linked to exercise capacity in stable patients.
- CRP levels do not appear to reflect the presence or severity of exercise-induced ischemia.
- Further research may clarify the role of CRP in cardiovascular risk stratification.