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Updated: Aug 18, 2026

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Published on: February 8, 2013
Prolactin induces growth-related gene expression in rat aortic smooth muscle in vivo
1Department of Immunology, Masonic Medical Research Laboratory, Utica, NY 13501-1787.
Abstract:
We examined the effects of in vivo administration of prolactin on growth-related gene expression in aorta. Optimal mRNA expression for both the proto-oncogene, c-myc and ornithine decarboxylase occurred at 22 mg/kg prolactin. For c-myc, this was seen as early as 15 min. Prolactin-induced ornithine decarboxylase mRNA expression began at 1 h. The results confirm work showing induction of these genes by prolactin in tissues where it is mitogenic and supports a role for prolactin in the trophic response of vascular smooth muscle.
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