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Aging and the neurocytoskeleton.

E Fifkova1, M Morales

  • 1Department of Psychology, University of Colorado, Boulder 80309.

Experimental Gerontology
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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Aging neurons show changes in their structure. This study found a slight increase in acetylated alpha-tubulin in older rats, suggesting alterations in neuronal cytoskeleton dynamics during aging.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Aging Research

Background:

  • Neuronal structure changes during senescence, with some neurons atrophying and others extending processes.
  • Microtubules, composed of tubulin, are crucial components of the neuronal cytoskeleton.

Purpose of the Study:

  • To investigate age-related changes in tubulin and acetylated alpha-tubulin levels in rat brains.
  • To explore potential alterations in cytoskeletal dynamics associated with neuronal aging.

Main Methods:

  • Analysis of tubulin and acetylated alpha-tubulin in brain homogenates from young (6 months) and old (24 months) Fischer 344 rats.
  • Utilized sodium dodecyl sulfate (SDS) extraction and Triton-solubilized fractionation methods.
  • Quantified total protein, total tubulin, and relative amounts of acetylated alpha-tubulin.

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Main Results:

  • No significant age-related differences were detected in total brain protein, total tubulin, or acetylated alpha-tubulin using SDS extracts.
  • A small, systematic increase in the relative amount of acetylated alpha-tubulin was observed in the Ca2+/cold insoluble fraction from older rats.
  • Findings align with existing literature on age-related cytoskeletal modifications.

Conclusions:

  • The study indicates a potential alteration in neuronal cytoskeletal dynamics during aging.
  • The observed increase in acetylated alpha-tubulin in specific fractions suggests subtle changes in microtubule stability or function with age.