Excess risk for contralateral breast cancer in CHEK2*1100delC germline mutation carriers
Annegien Broeks1, Lot de Witte, Anke Nooijen
1Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam.
Abstract:
We detected a significant excess risk for CHEK2*1100delC mutation carriers to develop a contralateral breast tumor, OR = 6.5 (95% CI 1.5-28.8, p = 0.005). The highest percentage of mutation carriers was detected among those bilateral breast cancer patients who had received radiation treatment for their first breast tumor. These results warrant prolonged medical surveillance and may indicate a clinically important interaction between CHEK2 heterozygosity and radiation in the development of contralateral breast cancer.
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