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Updated: Aug 19, 2026

Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface
Published on: February 23, 2020
Update on an exposure system for particles in the diagnosis of occupational asthma
1Institut de recherche en santé et sécurité du travail, Hôpital du Sacré-Coeur, Montreal, Canada.
Abstract:
We have previously designed a system for exposure to particles and described the preliminary results in 20 subjects exposed to occupational sensitizers in powder form (Cloutier Y, et al. - Eur Respir J, 1989; 2: 769). Modifications have been made to the particles generator, exposure chamber and sampling ports. Furthermore, in order to improve the stability of concentrations in the exposure chamber and to make the system easy to operate by a technician, it has been completely automated using closed-loop feedback regulated by a computer program.
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