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Related Experiment Videos

Mid-IR synchrotron radiation for molecular specific detection in microchip-based analysis systems.

S Kulka1, N Kaun, J R Baena

  • 1Institute of Chemical Technologies and Analytics, Vienna University of Technology, Getreidemarkt 164-AC, 1060, Vienna, Austria.

Analytical and Bioanalytical Chemistry
|March 5, 2004
PubMed
Summary

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New microchips enable high-resolution Fourier-transform infrared (FTIR) spectroscopy on-chip using synchrotron radiation. These devices offer micrometer-scale spatial resolution for advanced lab-on-a-chip applications in chemical analysis.

Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Materials Science

Background:

  • Microchip-based analysis systems require high spatial resolution for detecting small structures.
  • Fourier-transform infrared (FTIR) spectroscopy offers rich chemical information but often requires larger sample volumes or specialized equipment.
  • Mid-infrared (mid-IR) synchrotron radiation provides high brilliance, enabling diffraction-limited measurements.

Purpose of the Study:

  • To develop microstructures for microchip-based FTIR spectroscopic detection.
  • To leverage mid-IR synchrotron radiation for high-resolution chemical analysis on microfluidic devices.
  • To demonstrate the functionality of novel microchips for time-resolved and electrophoresis applications.

Main Methods:

  • Fabrication of microstructures using SU-8 polymer on calcium fluoride (CaF2) base plates.

Related Experiment Videos

  • Utilizing mid-IR synchrotron radiation for FTIR spectroscopic measurements.
  • Achieving diffraction-limited spot sizes, resulting in spatial resolutions of 5-20 micrometers.

    • Main Results:

    • Successful development of two types of microchips for FTIR analysis.
    • Demonstration of micrometer-scale spatial resolution, suitable for lab-on-a-chip devices.
    • Validation of operational functionality for time-resolved chemical reaction monitoring and chip-based electrophoresis with on-chip IR detection.

    Conclusions:

    • The developed microchips are functional and suitable for high-resolution FTIR spectroscopic detection.
    • These microchips show significant potential for applications in (bio)analytical chemistry, particularly in lab-on-a-chip systems.
    • The integration of FTIR spectroscopy with microfluidics opens new avenues for sensitive and spatially resolved chemical analysis.