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c-maf in multiple myeloma: an oncogene enhancing tumor-stroma interactions
Joachim Kienast1, Wolfgang E Berdel
1Department of Medicine, Hematology and Oncology, University of Muenster, D-48129 Muenster, Germany. kienast@uni-muenster.de
Cancer Cell
|March 5, 2004
Abstract:
Gene expression profiling studies reported by Hurt et al. in this issue of Cancer Cell reveal an unexpectedly frequent overexpression of c-maf in multiple myeloma and identify molecular targets of c-maf transactivation. The results define c-maf as a prototype of a class of oncogenes that not only stimulate cell cycle progression, but also promote pathological interactions between tumor and stroma cells.