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Updated: Aug 26, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
Regulation of transcriptional coactivator PGC-1alpha
Danielle Melloul1, Markus Stoffel
1Department of Endocrinology at Hadassah University Hospital, Jerusalem 91120, Israel.
Abstract:
Transcriptional coregulators modulate the activity of transcription factors and are required for the proper regulation of gene expression. One transcriptional coactivator, peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha), plays an important role in the control of energy metabolism and has been associated with type 2 diabetes. A recent paper by Fan et al. provides new information about the posttranslational regulation of PGC-1alpha activity. This Perspective discusses the implications of these findings with respect to diabetes and aging.
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