[Analyses of the allogeneic stem cell transplantation outcome based on the new risk classification]

To disclose the information for the risk in allogeneic hematopoietic stem cell transplantation (allo-HSCT), we propose a new concept of the risk in allo-HSCT. We analyzed all 94 allo-HSCT cases (86 patients) in our hospital since 1983. The overall survival rate was 56.4%. Among 27 patients considered to be at standard risk judged by conventional risk criteria who underwent initial transplantation from HLA-identical donors, 66.7% of them survived. Univariate statistical analyses among subgroups classified by conventional risk criteria and several reported prognostic factors show significant differences. However, all of them failed to show significant difference because of too much variation between cases in the same subgroup or a too small number of patients as compared with the U.S.A or European transplantation centers. We propose an alternative comprehensive classification of transplantation risk according to two newly-recognized distinct risks, disease state and transplantation risk. This comprehensive classification revealed significance in the multivariate statistical analyses in our hospital. We expect further discussion or the appearance of other beneficial nationwide proposals to evaluate and disclose the risk affecting survival following allo-HSCT.