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Updated: Aug 26, 2026

The Pocket-Creation Procedure of Endoscopic Submucosal Dissection for Large Rectal Laterally Spreading Tumors
Published on: February 13, 2026
[Infiltrating mucinous carcinoma developed on chronic anal fistula; diagnostic and surgical difficulties]
I N Mateş1, Daniela Dinu, Georgeta Rădulescu
1Spital Clinic Sfânta Maria, Clinica Chirurgie, bd. Ion Mihalache nr. 37-39, sector 1, Bucureşti, 78218.
Abstract:
Anal carcinoma is rare; fistula-in-ano is sometimes mentioned among other premalignant conditions. Chronic anal fistula is associated with malignant transformation to mucinous adenocarcinoma, difficult to diagnose in the anal region and associated to a poor prognosis. Malignant transformation to infiltrating colloid carcinoma was surprised during a one year period, in a patient with long-standing perianal fistula (24 years). Inflammatory changes of the perineal region and other peculiar characteristics (such as neoplastic spread following supurative pathways) were responsible for diagnostic and surgical difficulties.
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