Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MicroCT scanner performance and considerations for vascular specimen imaging.

Michael Marxen1, Michael M Thornton, Cameron B Chiarot

  • 1Sunnybrook & Women's College Health Sciences Centre, Department of Medical Biophysics, University of Toronto, Toronto, Canada.

Medical Physics
|March 6, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Changes in resting-state functional connectivity linked to affective symptoms: insights from a population-based study of adolescents and young adults.

Translational psychiatry·2026
Same author

Avoidance of parasitic fungi and nematode threats by <i>Tribolium castaneum</i>.

Behavioral ecology : official journal of the International Society for Behavioral Ecology·2026
Same author

Functional Outcome Prediction in Young Adults With Mental Health Symptoms Using Machine Learning and Large Language Models: Longitudinal Observational Study.

JMIR mental health·2026
Same author

Investigating Factors Associated With Spontaneous Remission in Individuals With Alcohol Use Disorder-Results From a Multi-Site Longitudinal Cohort Study.

Addiction biology·2026
Same author

Scientists' Warning on the Rapid Evolution of Parasites in the Anthropocene.

Evolutionary applications·2026
Same author

Health system resilience: quantifying the dynamic impact of environmental shocks on health service utilization using an interrupted time series and time-series forecasting approach in Western Province, Zambia.

The journal of climate change and health·2026

The General Electric Medical Systems MS8 microCT scanner effectively images small animal vasculature, detecting vessels under 20 micrometers. Contrast agent variability impacts imaging, but vessel diameter estimation is precise.

Area of Science:

  • Medical imaging
  • Biomedical engineering
  • Vascular biology

Background:

  • Three-dimensional vascular data is crucial for tumor characterization, blood flow modeling, and studying genetic effects on vascular development.
  • Microcomputed tomography (microCT) offers high-resolution imaging for biological specimens.

Purpose of the Study:

  • To evaluate the performance of the General Electric Medical Systems MS8 microCT scanner for imaging small animal vasculature.
  • To assess the efficacy of different contrast agents for microCT vascular imaging.

Main Methods:

  • The MS8 microCT scanner was used to image vascular systems of small animals.
  • Three contrast agents were tested: Batson's No. 17, MICROFIL MV122, and Baritop.
  • Image analysis included assessing resolution, field of view, voxel size, and vessel diameter estimation.

Related Experiment Videos

Main Results:

  • The MS8 scanner achieves high resolution (38 lp/mm) with small voxel sizes (8.5 micrometers).
  • Contrast varied significantly among agents and within vessels.
  • Vessels below 20 micrometers were detectable, and diameter estimation achieved 2-3 pixel precision.

Conclusions:

  • The MS8 microCT scanner is suitable for high-resolution vascular imaging in biomedical research.
  • Careful selection and application of contrast agents are necessary for optimal results.
  • The system enables detailed analysis of microvasculature, aiding in disease and developmental studies.