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Updated: Aug 26, 2026
Acute Myocardial Infarction in Rats
Published on: February 16, 2011
p38 MAPK mediates cardiovascular and behavioral responses induced by central IL-1 beta and footshock in conscious
Rui-mao Zheng1, Chang-jiang Zou, Shi-gong Zhu
1Department of Physiology and Pathophysiology, Health Science Center, Peking University, Beijing 100083, China.
Aim:
To investigate the roles of p38 mitogen-activated protein kinase (p38 MAPK) in the cardiovascular and behavioral responses induced by intracerebral ventricular injection (i.c.v.) of interleukin-1 beta (IL-1 beta) or footshock.
Methods:
We examined the effects of p38 MAPK on mean artery blood pressure (mABP), heart rate (HR), and motor activity (MA) during central administration of IL-1 beta, or footshock after i.c.v. SB203580 (a specific inhibitor of the p38 MAPK) with Cardiovascular and Behavior Telemetry System in conscious SD rats.
Results:
(1) IL-1 beta (i.c.v.) or footshock remarkably rise the mABP, and the maximal changes are (7.8+/-1.8) and (12.3+/-3.5) mmHg, respectively, which was abrogated by the pretreatment with p38 inhibitor SB203580 intracerebroventricularly. (2) Compared with icv saline group, the motor activity was significantly decreased in SB203580 group with maximal changes (-7.6+/-1.1) counts/min after footshock.
Conclusion:
p38 MAPK plays an important role in the pressor response induced by central administration of IL-1 beta or footshock and change of motor activity after footshock in conscious rats.
