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Prevalence of SSPE: a serological study
1Department of Microbiology, All India Institute of Medical Sciences, New Delhi.
Indian Pediatrics
|June 1, 1992
Summary
Subacute sclerosing panencephalitis (SSPE) was diagnosed in 40% of children with suspected measles virus infection. Measles antibodies were detected in serum and cerebrospinal fluid (CSF) of affected children.
Area of Science:
- Neurology
- Virology
- Pediatrics
Background:
- Subacute sclerosing panencephalitis (SSPE) is a rare, progressive neurological complication of measles virus infection.
- Early diagnosis of SSPE is crucial for management, though often challenging.
Purpose of the Study:
- To investigate the presence and levels of measles antibodies in serum and cerebrospinal fluid (CSF) of children clinically suspected of SSPE.
- To establish serological evidence for SSPE diagnosis in a pediatric cohort.
Main Methods:
- Analysis of 340 serum and CSF samples from children with suspected SSPE.
- Serological testing for measles antibodies in both serum and CSF.
Main Results:
- SSPE was confirmed in 138 (40%) of the children based on serological findings.
- The mean age of affected children was 8.2 years, with a male-to-female ratio of 5:1.
- Measles antibody titers ranged from 1:2 to 1:32 in CSF and 1:16 to 1:512 in serum.
Conclusions:
- Serological detection of measles antibodies in serum and CSF is a reliable diagnostic marker for SSPE in children.
- The findings highlight the utility of antibody profiling in confirming SSPE in clinically suspected cases.
Keywords:
Age FactorsAntibodies--analysisAsiaBiologyCentral Nervous SystemCentral Nervous System EffectsChildDemographic FactorsDeveloping CountriesDiseasesExaminations And DiagnosesImmunityImmunologic FactorsIndiaLaboratory Examinations And DiagnosesMeaslesMeasurementPhysiologyPopulationPopulation CharacteristicsPrevalenceResearch MethodologySouthern AsiaViral DiseasesYouth