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Related Experiment Videos

Gastric bypass surgery for morbid obesity leads to an increase in bone turnover and a decrease in bone mass.

Penelope S Coates1, John D Fernstrom, Madelyn H Fernstrom

  • 1Osteoporosis Prevention and Treatment Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

The Journal of Clinical Endocrinology and Metabolism
|March 6, 2004
PubMed
Summary
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Laparoscopic Roux-en-Y gastric bypass (LRGB) surgery for morbid obesity leads to increased bone resorption and decreased bone mass within 3-9 months. Further long-term studies are needed to understand these skeletal effects post-LRGB.

Area of Science:

  • Endocrinology
  • Metabolic Surgery
  • Bone Metabolism

Background:

  • The skeletal effects of laparoscopic Roux-en-Y gastric bypass (LRGB) surgery for morbid obesity are not well understood.
  • Rapid weight loss following bariatric surgery can impact bone health.

Purpose of the Study:

  • To investigate the short-term effects of LRGB on bone turnover and bone mineral density.
  • To compare skeletal markers in patients post-LRGB with matched obese controls.

Main Methods:

  • Cross-sectional comparison of 25 patients post-LRGB (11 months) with 30 obese controls.
  • Prospective study of 15 patients for 9 months after LRGB, monitoring weight, BMI, bone turnover markers, and bone mineral density.

Main Results:

Related Experiment Videos

  • Patients post-LRGB showed significantly lower weight and BMI compared to controls.
  • Markers of bone turnover (urinary N-telopeptide, osteocalcin) were significantly elevated post-LRGB.
  • Bone mineral density and content decreased significantly at the total hip, trochanter, and total body within 3-9 months post-LRGB.

    • Conclusions:

    • LRGB surgery in morbidly obese patients is associated with increased bone resorption and decreased bone mass within 3-9 months.
    • These findings highlight potential skeletal complications following LRGB surgery.
    • Long-term monitoring is essential to fully characterize the skeletal impact of LRGB.