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Updated: Aug 26, 2026
A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
[Investigation of cerebral blood volume measurement]
Keiichi Machida1, Motoharu Ootsu, Hideharu Nakano
1Department of Radiology, Toho University, Oomori Hospital.
Insights
Cerebral blood volume (CBV) is a useful indicator for predicting outcomes in patients with severe cerebral blood flow accidents. Reduced CBV in the thalamus was observed in serious cases, aiding in prognosis determination.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Cerebral blood flow (CBF) and cerebral blood volume (CBV) are critical indicators of brain health.
- Assessing these parameters aids in diagnosing and managing cerebrovascular conditions.
Purpose of the Study:
- To determine cerebral blood flow (CBF) and cerebral blood volume (CBV) in patients with cerebral blood flow accidents.
- To compare CBF and CBV values across different severity categories of the condition.
Main Methods:
- CBF was measured using xenon inhalation computed tomography (Xe CT).
- Transit time (TT) was assessed by perfusion CT, and CBV was calculated (CBV = CBF x TT).
- Patients were categorized into mild, moderate, and serious groups based on outcomes.
Main Results:
- A significant difference in CBF was found between mild (58.8±10.4 ml/100g/min) and moderate (40.2±19.4 ml/100g/min) cases in the thalamus.
- Serious cases showed decreased CBV in the thalamus.
- No significant difference in CBF was observed between mild and moderate cases.
Conclusions:
- Cerebral blood volume (CBV) is valuable for determining prognosis in severe cerebral blood flow accidents.
- CBV measurements can assist clinicians in assessing patient outcomes.
Purpose:
Cerebral blood blow (ml/100g/min) (CBF) and cerebral blood volume (%) (CBV) were determined in 102 patients (68 men and 34 women; average age, 55.6 years) with diagnostic cerebral blood flow accident.
Methods:
CBF was obtained by xenon inhalation computed tomography (Xe CT) and transit time (TT) by perfusion CT. CBV was calculated under the expression CBV=CBF x TT. The patients were divided into three categories: mild (outpatient), moderate (inpatient), and serious (dead), and CBF and CBV were compared between categories.
Results:
On regions of interest (ROI) in the thalamus, the value for mild cases was 58.8+/-10.4 ml/100g/min (CBF) and that for moderate cases was 40.2+/-19.4, a significant difference. In serious cases, CBV was decreased in the thalamus, but there was no difference in CBF between mild and moderate cases.
Conclusion:
CBV was useful for determining prognosis in severe cases of diagnostic cerebral blood flow accident.
