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[Mastalgia treatment with tamoxifen]
Carlos Manuel Ortíz-Mendoza1, Mario Alberto Lucas Flores, Enrique de Gaspe Domville Domville
1Servicio de Clínica de Mama, Hospital General Tacuba del ISSSTE.
Ginecologia Y Obstetricia De Mexico
|March 9, 2004
Summary
Tamoxifen effectively treats moderate to severe mastalgia (breast pain), with 67% of patients experiencing pain control. While side effects like dizziness occurred, most patients tolerated the treatment well.
Area of Science:
- Oncology
- Pharmacology
- Gynecology
Background:
- Mastalgia, or breast pain, is a common condition affecting many women.
- Various treatments exist, but efficacy and side effect profiles vary.
- Tamoxifen, a selective estrogen receptor modulator, has been explored for mastalgia management.
Purpose of the Study:
- To assess the effectiveness of tamoxifen in treating moderate to severe mastalgia.
- To document the incidence and types of side effects associated with tamoxifen therapy for mastalgia.
- To evaluate patient tolerance and treatment discontinuation rates.
Main Methods:
- A retrospective analysis of 141 women diagnosed with moderate to severe mastalgia.
- Data collected included patient demographics, mastalgia characteristics, tamoxifen dosage, treatment duration, and pain control outcomes.
- Side effects and treatment cessation were systematically recorded.
Main Results:
- The majority of patients were aged 41-50 years, experiencing non-cyclical mastalgia.
- Tamoxifen treatment, typically lasting 2-4 months, provided pain control in 67% of cases.
- 45% of patients reported side effects, most commonly dizziness and headache, with only 5.6% discontinuing treatment.
Conclusions:
- Tamoxifen demonstrates significant efficacy in managing moderate to severe mastalgia.
- The drug is generally well-tolerated, with a low rate of treatment discontinuation due to side effects.
- Tamoxifen represents a viable therapeutic option for women suffering from persistent breast pain.