Related Experiment Videos
Immunodeficiency associated with lymphosarcoma in a horse
M O Furr1, M V Crisman, J Robertson
1Marion duPont Scott Equine Medical Center, Leesburg, VA 22075.
Journal of the American Veterinary Medical Association
|July 25, 1992
Summary
A horse with lymphosarcoma showed immune dysfunction and immunoglobulin deficiency. Parenteral nutrition did not resolve these issues, suggesting a circulating immunosuppressive factor in the horse
Area of Science:
- Equine immunology
- Veterinary oncology
- Immunodeficiency disorders
Background:
- Disseminated lymphosarcoma in a 2-year-old horse.
- Diagnosed immune system dysfunction and immunoglobulin deficiency.
Observation:
- Prolonged parenteral nutrition (35 days) was administered.
- Nutritional support did not correct immunoglobulin deficiency.
- Lymphocyte phenotype testing revealed normal leukocyte proportions.
Findings:
- Lymphoblast transformation studies indicated a circulating immunosuppressive factor in the horse's serum.
- Normal lymphocyte function was observed when stimulated with precolostral equine serum.
Implications:
- Suggests a circulating immunosuppressive factor contributing to immune dysfunction in equine lymphosarcoma.
- Highlights the limitations of nutritional support in addressing specific immunodeficiencies.
- Warrants further investigation into immunosuppressive mechanisms in equine cancer.