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Related Experiment Videos

Anthelmintic activity of dioxapyrrolomycin.

G A Conder1, R J Zielinski, S S Johnson

  • 1Upjohn Laboratories, Parasitology Research and Chemical and Biological Screening, Kalamazoo, Michigan 49001.

The Journal of Antibiotics
|June 1, 1992
PubMed
Summary
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Dioxapyrrolomycin shows promise as a narrow-spectrum anthelmintic against Haemonchus contortus in jirds and lambs. It exhibits cross-resistance with closantel, suggesting a similar mode of action.

Area of Science:

  • Veterinary Parasitology
  • Antimicrobial Drug Discovery
  • Nematology

Background:

  • Parasitic nematodes pose significant threats to livestock health and productivity.
  • Novel anthelmintic compounds are needed due to increasing drug resistance.
  • Pyrrolomycin derivatives are known for their biological activities.

Purpose of the Study:

  • To evaluate dioxapyrrolomycin, pyrrolomycin C, pyrrolomycin D, and piericidin C2 as potential anthelmintics.
  • To determine the efficacy of these compounds against key veterinary nematode parasites.
  • To investigate the mode of action and spectrum of activity of dioxapyrrolomycin.

Main Methods:

  • In vitro testing against Caenorhabditis elegans.
  • In vivo efficacy studies in jirds infected with Haemonchus contortus and Trichostrongylus colubriformis.

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  • Efficacy trials in lambs infected with Haemonchus contortus.
  • In vitro migration assays to assess cross-resistance with closantel.

    • Main Results:

    • A crude extract containing the compounds showed activity against C. elegans and H. contortus in jirds.
    • Purified dioxapyrrolomycin demonstrated high efficacy (≥90.9%) against H. contortus in jirds and cleared 99.9% in lambs.
    • No tested compounds showed significant activity against T. colubriformis.
    • Dioxapyrrolomycin exhibited cross-resistance with closantel in H. contortus migration assays.

    Conclusions:

    • Dioxapyrrolomycin is an effective narrow-spectrum anthelmintic against Haemonchus contortus.
    • The mode of action of dioxapyrrolomycin is similar to that of closantel.
    • Further research into dioxapyrrolomycin as a veterinary anthelmintic is warranted.