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Kikuchi's disease.

Malathi Sathiyasekaran1, R Varadharajan, So Shivbalan

  • 1Kanchi Kamakoti Childs Trust Hospital,12-A, Nageswara Road, Nungambakkam, Chennai 600 034, India.

Indian Pediatrics
|March 9, 2004
PubMed
Summary
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A child presented with fever and swollen lymph nodes. Epstein-Barr virus (EBV) was detected, and lymph node biopsy confirmed Kikuchi's disease, a rare cause of lymphadenopathy.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Pathology

Background:

  • Cervical lymphadenopathy and fever are common pediatric symptoms requiring differential diagnosis.
  • Excluding serious conditions like sepsis, malignancy, and autoimmune diseases is crucial in pediatric lymphadenopathy workup.

Observation:

  • An 11-year-old girl exhibited intermittent high-grade fever and significant enlargement of left cervical lymph nodes.
  • Systemic examination revealed no other significant abnormalities.

Findings:

  • Initial investigations for sepsis, malignancy, and autoimmune disorders were negative.
  • Positive Viral Capsid Antigen IgM (VA-IgM) for Epstein-Barr Virus (EBV) was noted.
  • Lymph node histopathology confirmed Kikuchi's disease, also known as Kikuchi-Fujimoto disease.

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Implications:

  • This case highlights Kikuchi's disease as a potential diagnosis in children presenting with fever and cervical lymphadenopathy.
  • The co-occurrence of EBV serology requires careful interpretation in the context of Kikuchi's disease.
  • Further research into the etiology and management of pediatric Kikuchi's disease is warranted.