Related Experiment Video
Updated: Aug 25, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
[Lung and middle ear tuberculosis]
Abstract:
A hundred and forty patients with destructive pulmonary tuberculosis who suffered concurrently from purulent otitis were examined. Of them, 7 (5%) patients were found to have tuberculosis of the middle ear and to have Mycobacterium tuberculosis in the sputum and otic discharge. These 7 patients were diagnosed as having disseminated destructive pulmonary tuberculosis for as long as 10 years. Tuberculosis of the middle ear was regarded as a secondary disease that occurs hematogeneously as most patients were observed to have in the lung active tuberculosis and dissemination foci throughout the lung fields with significant signs of tuberculous intoxication when tuberculous otitis was detected. Clinical cure of tuberculosis of the middle ear was noted in 2 patients; a stable dry perforation of the tympanic membrane was developed in 5. The mean duration of therapy was 169 days. Due to therapy, there was stabilization of pulmonary and extrapulmonary tuberculosis with bacterial absence in the sputum and otic discharge of all the patients.
Related Concept Videos
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Tuberculosis
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...