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Related Experiment Videos

Gamma/delta T cell lymphoma.

Akihiko Taguchi1, Mutsuko Miyazaki, Shizu Sakuragi

  • 1Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu 747-8511.

Internal Medicine (Tokyo, Japan)
|March 10, 2004
PubMed
Summary

This study reports a rare case of hepatosplenic gammadelta T cell lymphoma (GDTL) in a 54-year-old woman. Despite CHOP chemotherapy, the aggressive lymphoma led to fatal intestinal hemorrhage.

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Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Hepatosplenic gammadelta T cell lymphoma (GDTL) is an aggressive extranodal non-Hodgkin lymphoma.
  • GDTL is characterized by the infiltration of malignant gammadelta T cells into the liver, spleen, and bone marrow.

Observation:

  • A 54-year-old woman presented with fever and hepatosplenomegaly.
  • Liver biopsy showed sinusoidal lymphocyte infiltration; spleen biopsy revealed red pulp infiltration positive for CD3, CD43, CD45RO, and TIA-1, with spared white pulp.
  • Spleen cells exhibited T-cell receptor (TCR) gene rearrangements and Epstein-Barr virus (EBV) DNA.
  • Peripheral blood and bone marrow revealed atypical lymphocytes, chromosomal abnormalities (del(13)(q12q14), trisomy 8), and RB gene breakage.
  • Elevated serum vascular endothelial growth factor (VEGF) was noted.

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Findings:

  • The patient was diagnosed with hepatosplenic gammadelta T cell lymphoma (GDTL).
  • Genetic analysis confirmed T-cell receptor gene rearrangement and EBV presence.
  • Cytogenetic analysis revealed specific chromosomal abnormalities and RB gene damage.

Implications:

  • This case highlights the diagnostic challenges and aggressive nature of GDTL.
  • The ineffectiveness of standard CHOP chemotherapy underscores the need for novel therapeutic strategies for GDTL.
  • Understanding the genetic and viral associations may offer targets for future treatments.