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Tissue factor: a key molecule in hemostatic and nonhemostatic systems.
1Biochemistry Department, College of Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA. jhmorris@uiuc.edu
International Journal of Hematology
|March 10, 2004
Summary
Tissue factor (CD142) is crucial for blood clotting and implicated in thrombotic diseases. Emerging research reveals its non-hemostatic roles in cell signaling, inflammation, and cancer progression.
Area of Science:
- Biochemistry
- Molecular Biology
- Pathology
Background:
- Tissue factor (CD142) initiates blood coagulation via factor VIIa activation after vascular injury.
- Its role in hemostasis is critical, but it also contributes to thrombotic diseases like disseminated intravascular coagulation.
- Recent studies highlight non-hemostatic functions, including cell signaling and tumor metastasis.
Purpose of the Study:
- To review the established roles of tissue factor in hemostasis and thrombosis.
- To explore novel insights into tissue factor's non-hemostatic functions.
- To discuss the potential involvement of circulating tissue factor in thrombotic events.
Main Methods:
- Literature review of existing research on tissue factor.
- Analysis of studies investigating tissue factor's molecular mechanisms.
- Synthesis of findings on both hemostatic and non-hemostatic roles.
Main Results:
- Tissue factor is essential for normal hemostasis and pathological thrombosis.
- Evidence supports tissue factor's involvement in cell signaling pathways.
- Tissue factor contributes to tumor growth, angiogenesis, and metastasis.
Conclusions:
- Tissue factor is a multifaceted protein with critical roles in both blood clotting and non-hemostatic processes.
- Understanding its diverse functions is key to developing new therapeutic strategies for thrombosis and cancer.
- Further research into blood-borne tissue factor is warranted to elucidate its role in thrombosis.