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Related Experiment Videos

Nutrients and botanicals for erectile dysfunction: examining the evidence.

Douglas McKay1

  • 1Thorne Research, PO Box 25, Dover, ID 83825. duffy@thorne.com

Alternative Medicine Review : a Journal of Clinical Therapeutic
|March 10, 2004
PubMed
Summary

Erectile dysfunction is common, and many natural products claim to help. Some evidence suggests arginine, yohimbine, Panax ginseng, Maca, and Ginkgo biloba may improve erectile function.

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Area of Science:

  • Integrative medicine and men's health.

Background:

  • Erectile dysfunction (ED) impacts 50% of men aged 40-70 in the U.S.
  • ED is a significant public health concern, with numerous natural products marketed for sexual vitality.

Purpose of the Study:

  • To review empirical evidence on natural products for erectile dysfunction.
  • To identify compounds with potential efficacy for ED.

Main Methods:

  • Literature review of available empirical evidence on natural products for ED.
  • Analysis of clinical trial data supporting efficacy.

Main Results:

  • Most natural compounds lack sufficient clinical trials for efficacy.
  • Arginine, yohimbine, Panax ginseng, Maca, and Ginkgo biloba show some evidence for ED.

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  • A common mechanism may involve enhanced penile endothelial L-arginine-nitric oxide activity.

    • Conclusions:

    • While many natural products exist, few are rigorously studied for ED.
    • Specific agents like arginine, yohimbine, Panax ginseng, Maca, and Ginkgo biloba warrant further investigation for ED treatment.
    • Nitric oxide pathway modulation is a potential unifying mechanism for these natural agents.