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Related Experiment Videos

Two peptidase activities decrease in treated bipolar disorder not schizophrenic patients.

Gerome Breen1, Adrian J Harwood, Kathryn Gregory

  • 1Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, Kings College London, London, UK.

Bipolar Disorders
|March 10, 2004
PubMed
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Plasma prolyl oligopeptidase (PO) and Z-Pro-prolinal-insensitive peptidase (ZIP) activities are decreased in bipolar disorder patients. This study differentiates these enzymes, revealing significant reductions in both PO and ZIP in treated BD patients, but not in schizophrenic patients.

Area of Science:

  • Biochemistry
  • Neuroscience
  • Psychiatry

Background:

  • Prolyl oligopeptidase (PO) inhibition affects mood stabilizer efficacy in neuronal cultures.
  • Abnormal plasma PO activity is linked to bipolar disorder (BD) and schizophrenia.
  • A novel enzyme, Z-Pro-prolinal-insensitive peptidase (ZIP), cleaves the same substrate as PO, complicating previous findings.

Purpose of the Study:

  • To develop an assay distinguishing between PO and ZIP activities.
  • To measure and compare plasma PO and ZIP activities in BD patients, schizophrenic patients, and controls.

Main Methods:

  • Developed a specific assay to differentiate PO and ZIP enzyme activities.
  • Measured plasma PO and ZIP activities in 48 BD patients, 50 schizophrenic patients, and 50 controls.

Related Experiment Videos

  • Compared enzyme activities between patient groups and controls.

    • Main Results:

    • ZIP activity is localized to blood plasma, while PO activity is found in lymphocyte cytosol and plasma.
    • BD patients undergoing treatment showed significant decreases in both plasma PO and ZIP activities compared to controls.
    • No significant changes in plasma PO or ZIP activities were observed in schizophrenic patients.

    Conclusions:

    • Plasma PO activity previously measured actually comprises both PO and ZIP activities.
    • This study demonstrates a statistically significant decrease in both PO and ZIP enzymes in BD patients on lithium treatment.
    • No significant alterations in PO or ZIP activity were found in schizophrenic patients.