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S100B in schizophrenic psychosis.

Matthias Rothermundt1, Gerald Ponath, Volker Arolt

  • 1Department of Psychiatry, University of Muenster, D-48149 Muenster, Germany.

International Review of Neurobiology
|March 10, 2004
PubMed
Summary

Schizophrenia pathogenesis may involve neuronal synapse and dendrite dysfunction. This review examines the role of S100B (S100 calcium-binding protein B), an astrocytic protein, in brain development and disease.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cell Biology

Background:

  • Neuronal synapse and dendrite dysfunction is increasingly implicated in schizophrenia pathogenesis.
  • This dysfunction may occur during neurodevelopment and in mature brain processes.
  • S100B, a calcium-binding astrocytic protein, influences neuronal and glial cell growth and brain immunity.

Purpose of the Study:

  • To review cell culture and animal studies relevant to schizophrenia pathogenesis.
  • To analyze morphological and functional data concerning S100B.
  • To evaluate clinical studies on S100B concentrations in schizophrenia patients.

Main Methods:

  • Literature review of cell culture experiments.
  • Analysis of animal model data.
  • Review of clinical studies on S100B levels in schizophrenia.

Main Results:

  • S100B modulates neuron and glia proliferation and differentiation.
  • S100B is involved in regulating brain energy metabolism and immune functions.
  • Alterations in S100B concentrations have been reported in schizophrenic patients.

Conclusions:

  • S100B is a potential factor in schizophrenia pathogenesis.
  • Further research is needed to clarify S100B's precise role.
  • Investigating S100B offers promising research avenues for schizophrenia.

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