Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

What is transforming growth factor-beta (TGF-beta)?

David Chin1, Glen M Boyle, Peter G Parsons

  • 1Melanoma Genomics and Head and Neck Group, Queensland Institute of Medical Research, Herston, QLD, Australia. davidCqimr.edu.au

British Journal of Plastic Surgery
|March 10, 2004
PubMed
Summary

The Transforming Growth Factor-beta (TGF-beta) superfamily has complex, opposing effects. Further research into its signaling pathways and receptors is crucial for understanding its functions and developing new therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Momentum-Resolved X-Ray Thomson Scattering Benchmark of Electronic-Response Models in Warm Dense Aluminium.

Physical review letters·2026
Same author

A BRN2:MYC transcriptional axis regulates interconversion between therapy-resistant and tumorigenic phenotypes in melanoma.

Cell reports·2025
Same author

Spatial Transcriptomics Reveals Novel Mechanisms Involved in Perineural Invasion in Pancreatic Ductal Adenocarcinomas.

Cancers·2025
Same author

Pathogenesis of polypropylene mesh complications in female pelvic floor surgery.

American journal of obstetrics and gynecology·2025
Same author

Epoxytiglianes induce keratinocyte wound healing responses via classical protein kinase C activation to promote skin re-epithelialization.

Biochemical pharmacology·2024
Same author

Effectiveness of Implementation of an Enhanced Recovery Program in Bariatric Surgery.

The Journal of surgical research·2024

Area of Science:

  • Cellular and Molecular Biology
  • Immunology
  • Biochemistry

Background:

  • The Transforming Growth Factor-beta (TGF-beta) superfamily of proteins exhibits diverse and often opposing biological effects across various cell types and tissues.
  • The intricate structure and multifaceted functions of TGF-beta, along with the variability of its downstream targets, contribute to an incomplete understanding of its activation mechanisms and modes of action.

Purpose of the Study:

  • To investigate the complex signaling pathways and receptor interactions of the TGF-beta superfamily.
  • To compare the bioactivities of TGF-beta cytokines across different cell types.
  • To track the physiological and immunological effects of TGF-beta in vivo.

Main Methods:

  • Focus on analyzing TGF-beta receptors and intercellular signaling cascades.

Related Experiment Videos

  • Comparative bioactivity assessments across diverse cellular contexts.
  • In vivo studies to monitor physiological and immunological responses.

    • Main Results:

    • Current research highlights the complexity of TGF-beta signaling.
    • Variability in downstream targets complicates understanding of its diverse effects.
    • Ongoing studies are elucidating in vivo physiological and immunological impacts.

    Conclusions:

    • A deeper understanding of TGF-beta superfamily activation and function is needed.
    • Future research holds promise for significant therapeutic applications.
    • The ability to manipulate these proteins in vivo is a key future goal.