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Updated: Aug 25, 2026

Metal-Limited Growth of Neisseria gonorrhoeae for Characterization of Metal-Responsive Genes and Metal Acquisition from Host Ligands
Published on: March 4, 2020
Iron transport systems in Neisseria meningitidis
Donna Perkins-Balding1, Melanie Ratliff-Griffin, Igor Stojiljkovic
1Rollins Research Center, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA. dbaldin@emory.edu
Abstract:
Acquisition of iron and iron complexes has long been recognized as a major determinant in the pathogenesis of Neisseria meningitidis. In this review, high-affinity iron uptake systems, which allow meningococci to utilize the human host proteins transferrin, lactoferrin, hemoglobin, and haptoglobin-hemoglobin as sources of essential iron, are described. Classic features of bacterial iron transport systems, such as regulation by the iron-responsive repressor Fur and TonB-dependent transport activity, are discussed, as well as more specific features of meningococcal iron transport. Our current understanding of how N. meningitidis acquires iron from the human host and the vaccine potentials of various components of these iron transport systems are also reviewed.
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