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Published on: October 3, 2012
Bilineal transmission of Parkinson disease on Crete suggests a complex inheritance
Cleanthe Spanaki1, Andreas Plaitakis
1Department of Neurology, University of Crete, Medical School, Heraklion, Crete, Greece.
Abstract:
The authors studied Parkinson disease (PD) in natives of Crete, a population sharing a common genetic and cultural background. Analysis of data from 247 index PD cases revealed a hereditary component for PD (OR 3.37; p < 0.001 for a first-degree relative of a PD patient). In 12 bilineal families (PD originating from both parental sides) identified, a high proportion (43%) of bilineal members had PD, but only 5.7% of their offspring were affected. These data suggest a recessive or an oligogenic inheritance for PD.
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