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Related Experiment Videos

A functional on-chip pressure generator using solid chemical propellant for disposable lab-on-a-chip.

Chien-Chong Hong1, Suresh Murugesan, Sanghyo Kim

  • 1MicroSystems and BioMEMS Lab, Department of Electrical and Computer Engineering and Computer Science, University of Cincinnati, PO Box 210030, Cincinnati, OH 45221-0030, USA.

Lab on a Chip
|March 10, 2004
PubMed
Summary

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A novel on-chip pressure generator uses chemical energy from azobis-isobutyronitrile (AIBN) to precisely control fluid delivery in disposable biochips. This system offers a reliable, compact, and integrated pressure source for lab-on-a-chip applications.

Area of Science:

  • Microfluidics
  • Chemical Engineering
  • Materials Science

Background:

  • Disposable biochips and lab-on-a-chip systems require precise fluid handling.
  • Existing pressure generation methods can be complex or lack integration capabilities.
  • A need exists for compact, reliable, and on-demand pressure sources for microfluidic devices.

Purpose of the Study:

  • To develop and characterize a functional on-chip pressure generator utilizing chemical energy.
  • To demonstrate the capability of the device for fluidic delivery in microfluidic channels.
  • To evaluate the potential of this system for disposable lab-on-a-chip applications.

Main Methods:

  • Utilized azobis-isobutyronitrile (AIBN) as a solid chemical propellant deposited via screen-printing on a microheater.

Related Experiment Videos

  • Controlled nitrogen gas generation and output pressure by regulating microheater input power and AIBN quantity.
  • Experimentally measured pressure output and demonstrated fluidic delivery of water through a microfluidic channel.

    • Main Results:

    • Achieved approximately 3,000 Pa pressure with 189 mJ energy input to 100 µg of AIBN.
    • Successfully drove 50 nl of water through a 70 mm microfluidic channel (100 µm x 50 µm cross-section).
    • Demonstrated adjustable pressure output by controlling heating power and propellant amount.

    Conclusions:

    • The developed on-chip pressure generator offers a compact, reliable, and easily integrated solution for fluidic delivery.
    • Biologically inert nitrogen gas output makes it suitable for sensitive biochemical analyses and drug delivery systems.
    • This chemical energy-based system presents a promising alternative for powering disposable microfluidic devices.