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Updated: Aug 8, 2026
Preparation of Herbal Medicine: Er-Xian Decoction and Er-Xian-containing Serum for In Vivo and In Vitro Experiments
Published on: May 31, 2017
[Intercepting effects of seven Chinese herb drugs on experimental oral carcinogenesis]
Wei-xin Zhang1, Hui-fang Hu, Wei-guo Li
1Department of Oral Medicine, Shanghai Ninth People's Hospital, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China.
Purpose:
To screen effective chemopreventive Chinese herb drugs on experimental oral carcinogenesis.
Methods:
410 golden hamsters were randomly divided into positive control group,negative control group and 7 experimental groups(Radix et Rhizoma Thalictri, Radix Sophorae Tonkinesis, Pseudobulbus Cremastrae appendiculate, Rhizoma Acori Tatarinowii, Radix Angelicae seu Heraclei, Rhizoma Curcumae, Fructus Trichosanthis). 7,12-Dimethylbenz(a)anthracene(DMBA) was used to induce oral carcinogenesis in hamster cheek pouch, 7 liquid Chinese herb drugs were respectively injected into the stomach of the hamsters before and during oral carcinogenesis. Specimens were observed by histopathologic method, and the results were analysized statistically.
Results:
Compared with positive control group, the prevalence of displasia was significantly reduced in group Radix Sophorae Tonkinesis and Radix Angelicae Dahuricae, but significant decrease could not be found in other experiment groups.
Conclusion:
Radix Sophorae Tonkinesis and Radix Angelicae Dahuricae could effectively intercept DMBA-induced oral carcinogenesis in hamster.
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