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AlIII ion complexes of saccharic acid and mucic acid: a solution and solid-state study
Andrea Lakatos1, Roberta Bertani, Tamas Kiss
1Biocoordination Chemistry Research Group, of the Hungarian Academy of Sciences, University of Szeged, PO Box 440, 6701 Szeged, Hungary.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|March 10, 2004
Summary
This study reveals how aluminum (Al(III)) binds to D-saccharic and mucic acids, forming stable dimeric complexes. These complexes maintain their structure in solution and can exist in different isomeric forms.
Area of Science:
- Inorganic Chemistry
- Coordination Chemistry
- Supramolecular Chemistry
Background:
- Aldaric acids, such as D-saccharic acid and mucic acid, are polyhydroxy dicarboxylic acids with potential metal-binding properties.
- Understanding metal-ligand interactions is crucial for various applications, including environmental remediation and medicinal chemistry.
Purpose of the Study:
- To investigate the Al(III)-binding abilities of D-saccharic acid and mucic acid in solution.
- To determine the structural characteristics and isomeric forms of the formed aluminum complexes.
- To elucidate the coordination modes and stability of these complexes.
Main Methods:
- Solution studies utilizing pH potentiometry, Nuclear Magnetic Resonance ((1)H and (13)C NMR), and Electrospray Ionization Mass Spectrometry (ESI-MS).
- Density Functional Theory (DFT) calculations to determine probable conformations and binding modes.
- Isolation and crystallographic characterization of a solid D-saccharic acid-aluminum complex.
Main Results:
- The coordination involves the alcoholic hydroxy groups adjacent to the terminal carboxylate groups of the aldaric acids.
- A solid complex, K(2)[[Al(LH(-2))(H(2)O)](2)].H(2)O, was successfully isolated and characterized.
- ESI-MS and NMR confirmed the structural integrity of the complex in solution, existing in potentially two isomeric forms.
- DFT calculations identified stabilizing orbitals contributing to the dimeric structure.
Conclusions:
- D-saccharic acid and mucic acid effectively bind Al(III), forming stable dimeric complexes.
- The complexes exhibit structural stability in solution and can exist as isomers depending on ligand and pH.
- The study provides insights into the coordination chemistry of aldaric acids with trivalent aluminum.