Related Experiment Video
Updated: Aug 25, 2026

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
Three-dimensional geometrical characterization of cerebral aneurysms
Baoshun Ma1, Robert E Harbaugh, Madhavan L Raghavan
1Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242-1527, USA.
Abstract:
The risk of rupture of cerebral aneurysms has been correlated with the size of the aneurysm sac. It is conceivable that geometrical shape, not just size may also be related to aneurysm rupture potential. Further, aneurysm shape may also be a factor in deciding on treatment modalities, i.e., to clip or coil. However, our ability to make use of available information on aneurysm shape remains poor. In this study, methods were developed to quantify the seemingly arbitrary three-dimensional geometry of the aneurysm sac, using differential and computational geometry techniques. From computed tomography angiography (CTA) data, the three-dimensional geometry of five unruptured human cerebral aneurysms was reconstructed. Various indices (maximum diameter, neck diameter, height, aspect ratio, bottleneck factor, bulge location, volume, surface area, Gaussian and mean curvatures, isoperimetric ratio, and convexity ratio) were utilized to characterize the geometry of these aneurysm surfaces and four size-matched hypothetical control aneurysms. The physical meanings of various indices and their possible role as prognosticators for rupture risk and presurgical planning were discussed.
Related Concept Videos
Anatomy of the Brain: Ventricles
Aneurysm III: Interprofessional Care
Aneurysm I: Introduction
Cylinders in Three-Dimensional Space
Aneurysm II: Clinical Manifestations and Diagnostic Studies
