Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal damage in vesico-ureteric reflux.

P Caione1, G Ciofetta, G Collura

  • 1Division of Paediatric Urology, Department of Nephrology and Urology, Bambino Gesù Children's Hospital, Research Institute, Rome, Italy. caione@opbg.net

BJU International
|March 11, 2004
PubMed
Summary

Vesico-ureteric reflux (VUR) often causes renal parenchymal damage, with reduced kidney function worsening with reflux severity. This study highlights VUR

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for Fractionally Charged Particles in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2025
Same author

Observation of the <math> </math> decay.

The European physical journal. C, Particles and fields·2024
Same author

Observation of the ϒ(3S) Meson and Suppression of ϒ States in Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2024
Same author

Search for Narrow Trijet Resonances in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2024
Same author

Search for exotic decays of the Higgs boson to a pair of pseudoscalars in the <math></math> and <math></math> final states.

The European physical journal. C, Particles and fields·2024
Same author

Observation of WWγ Production and Search for Hγ Production in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2024

Area of Science:

  • Pediatric Nephrology
  • Radiology
  • Urology

Background:

  • Primary vesico-ureteric reflux (VUR) is a common condition in children.
  • Renal parenchymal damage is a significant complication of VUR.
  • Understanding the patterns and extent of damage is crucial for management.

Purpose of the Study:

  • To determine the extent of renal parenchymal involvement in primary VUR.
  • To analyze the relationship between VUR grade, patient age, and patterns of renal damage.
  • To evaluate renal function using 99mTc-DMSA scintigraphy.

Main Methods:

  • Retrospective analysis of 197 children with primary VUR.
  • Voiding cysto-urethrography (VCUG) and 99mTc-dimercaptosuccinic acid (DMSA) renal scintigraphy were performed.

Related Experiment Videos

  • DMSA scans classified into single scar (SS), multiple scarring (MS), or diffuse reduced uptake with small renal size.

    • Main Results:

    • 67% of refluxing units showed renal damage, compared to 16% of non-refluxing units.
    • Absolute uptake (AU) decreased significantly with increasing VUR grade (P < 0.001).
    • Severe VUR (grade 4-5) was associated with multiple scarring (MS) and reduced renal size, particularly in younger children (< 2 years).

    Conclusions:

    • VUR is frequently associated with renal parenchymal damage.
    • Renal function (AU) declines progressively with VUR severity.
    • Severe VUR leads to more extensive scarring and reduced kidney size, impacting function.