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Related Experiment Videos

rhBMP-2 significantly enhances guided bone regeneration.

Ulf M E Wikesjö1, Mohammed Qahash, Robert C Thomson

  • 1Laboratory for Applied Periodontal and Craniofacial Regeneration, Department of Periodontology, Temple University School of Dentistry, Philadelphia, PA 19140, USA. ulf.wikesjo@temple.edu

Clinical Oral Implants Research
|March 11, 2004
PubMed
Summary

Recombinant human bone morphogenetic protein-2 (rhBMP-2) with an absorbable collagen sponge (ACS) significantly enhanced bone regeneration in alveolar defects. This combination, used with a space-providing device, shows promise for dental implant procedures.

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Area of Science:

  • Oral and Maxillofacial Surgery
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Guided bone regeneration (GBR) has limited bone augmentation potential in horizontal alveolar defects.
  • Recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge (ACS) carrier enhances bone regeneration but often yields insufficient bone for implant dentistry.
  • A space-providing, macro-porous expanded polytetrafluoroethylene (ePTFE) device may improve GBR outcomes.

Purpose of the Study:

  • To evaluate the efficacy of rhBMP-2/ACS in enhancing GBR.
  • To assess the impact of a space-providing ePTFE device on rhBMP-2/ACS-mediated bone regeneration.
  • To compare bone augmentation in defects treated with rhBMP-2/ACS versus control.

Main Methods:

  • Bilateral, critical-size, supra-alveolar defects were created in mongrel dogs.

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  • Titanium dental implants were placed, and defects were treated with either rhBMP-2/ACS or buffer/ACS (control).
  • A space-providing ePTFE device covered the constructs, and flaps were closed primarily. Analysis was performed at 8 weeks.

    • Main Results:

    • rhBMP-2/ACS significantly enhanced bone formation compared to controls.
    • Vertical bone gain and new bone area were substantially greater in the rhBMP-2/ACS group.
    • Bone-implant contact percentages did not significantly differ between rhBMP-2/ACS treated bone and control resident bone, nor between implant surface types.

    Conclusions:

    • rhBMP-2/ACS significantly enhances GBR in conjunction with a space-providing ePTFE device.
    • The study demonstrates improved bone regeneration for dental implant applications.
    • Dental implant surface technology did not significantly influence bone formation in this study.