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[Relationship between polymorphisms of cystathionine beta-synthase gene and stroke]
Le Fang1, Wei Wu, Ying-quan Wu
1Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun 130031, Jilin, China.
Objective:
To determine whether the T27796C mutation in cystathionine beta-synthase (CBS) gene is associated with stroke in Chinese.
Methods:
The T27796C mutation in CBS gene of 59 cases with stroke and 65 health controls were detected by polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP).
Results:
As this investigation shown, the frequencies of two alleles of T27796C mutation were followed: C was 56.8%, T was 43.2% in cases and C was 51.5%, T was 48.5% in controls. T27796C mutation had no obvious relativity to the stroke (P>0.05). There was no significant difference in frequency of alleles of this mutation between cases and controls (CC: 35.6% vs. 24.6%; CT: 42.4% vs. 53.8%; TT: 22.0% vs. 21.5%; all P>0.05). There was not obvious difference in frequency of alleles of this mutation between hemorrhagic patients and ischemic stroke patients (all P>0.05).
Conclusion:
T27796C mutation in CBS is not obviously correlated with stroke and this mutation is not associated with categories of stroke.