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Updated: Aug 17, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
Newly recognized physiologic and pathophysiologic actions of the angiotensin-converting enzyme
Sebastien Fuchs1, Kristen Frenzel, Hong D Xiao
1Department of Pathology, Emory University, 101 Woodruff Circle, Atlanta, GA 30322, USA.
Abstract:
Despite several decades of research into the renin-angiotensin system, new aspects of this endocrine system are elucidated every few years, expanding its role not only in hypertension but also in diabetes, oncology, and cardiology. In this review, we describe newly recognized physiologic actions of the angiotensin-converting enzyme (ACE). These include the role of local versus systemic ACE in maintaining blood pressure, the physiology of bradykinin accumulation during ACE inactivation, and the role of alternate "non-angiotensin" substrates and potential non-enzymatic properties of ACE.
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