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Related Experiment Videos

Aganglionosis in rodents.

D T Cass1, A L Zhang, J Morthorpe

  • 1Department of Pediatric Surgery, Westmead Hospital, Australia.

Journal of Pediatric Surgery
|March 1, 1992
PubMed
Summary

Aganglionosis of the bowel involves issues with vagal neural crest cell migration or the gut's microenvironment. This study in rodent models indicates defects occur over an extended bowel area, not just the terminal colon.

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Area of Science:

  • Developmental biology
  • Gastroenterology
  • Neuroscience

Background:

  • The cause of aganglionosis of the bowel, a condition affecting the enteric nervous system, is debated.
  • Historically, defects in vagal neural crest cell migration were implicated.
  • Recent theories suggest a defective gut microenvironment may impede neural crest cell migration.

Purpose of the Study:

  • To investigate the etiology of aganglionosis of the bowel.
  • To differentiate between neural crest cell migration defects and microenvironmental influences.

Main Methods:

  • Histological analysis of three rodent models.
  • In vivo studies using kidney capsule transplantation.
  • In vitro studies utilizing tissue culture.

Main Results:

  • Early vagal neural crest cell migration to the stomach showed no difference between mutant and normal embryos.
  • Migration through the small bowel was normal in mice but slowed in rats.
  • Enteric precursor migration into the colon was progressively slowed in mutant mice, detectable before the terminal aganglionic region.

Conclusions:

  • Aganglionosis results from defects in either vagal neural crest cell migration or the gut microenvironment over a significant bowel segment.
  • Alterations in enteric neuron appearance and gut mesenchyme were observed in mutants.
  • The primary initiating event requires further investigation.

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